We recently reported the discovery of a small molecule inhibitor, AI-10-49 which can specially inhibit the protein-protein interaction between RUNX1 tumor suppressor and CBF-SMMHC oncogene. We also demonstrated that AI-10-49 can re-establish the RUNX1 transcriptional program in inv(16) cells and can extend the survival of inv(16) leukemic mice. To identify the transcriptional changes associated with AI-10-49, we performed RNA-seq analysis in ME-1 cells [human inv(16) leukemia cell line] treated with AI-10-49. SOURCE: Lucio Castilla (lucio.castilla@umassmed.edu) -  University of Massachusetts

Pluto Bioinformatics

GSE101788: Global transcriptional changes associated with AI-10-49 in inv(16) leukemic cells [RNA-seq]