Pluto Bioinformatics

GSE135691: RNASeq of bone lining niche cell components from healthy vs. myeloma-bearing mice

Bulk RNA sequencing

We compare gene expression in FACS-sorted bone-lining cell components: stromal progenitors, osteoprogenitors and endothelial cells, from myeloma-bearing vs. from healthy mice, and also between myeloma cells flushed from the central bone marrow vs. myeloma cells digested from the bone surface (myeloma-bearing mice only). The myeloma model used is the 5TGM1 murine myeloma cell line, injected into immunocompetent KaLwRij mice. SOURCE: Sarah Gooding (sarah.gooding@rdm.ox.ac.uk) - Drakesmith Lab Oxford University