Pluto Bioinformatics

GSE101772: Fibroblast-specific genetic dissection of TGF-Smad2/3 signaling in cardiac fibrosis

Bulk RNA sequencing

Overall goal: To elucidate fibroblast-specific role of TGF-Smad2/3 signaling in fibroblast activation and their differentiation to myofibroblasts. Purpose of analysis: To generate transcriptional profile of Smad2/3 and TGFreceptors1/2-deficient fibroblasts in the context of pathological cardiac fibrosis. SOURCE: Vikram Prasad Cincinnati Children's Hospital Medical Center