Pluto Bioinformatics

GSE112213: Next Generation Sequencing of LdlrKO LXR-phosphorylation disrupted macrophage transcriptomes

Bulk RNA sequencing

Liver X Receptors (LXR and ) are ligand-activated transcription factors that play a key role in the control of lipid homeostasis, as well as modulation of immunity and inflammation. Besides ligand binding, LXR activity can be regulated by posttranslational modifications, such as phosphorylation. This study aims to assess changes in bone marrow derived macrophage transcriptional profiles of mice that carry LysMcre directed phosphorylation deficient-version of LXR compared (S196A) to wild-type (WT). SOURCE: Ines Pineda-Torra ( - University College London

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