Pluto Bioinformatics

GSE137170: Transcriptome reprogramming via Tob2-promoted global mRNA turnover

Bulk RNA sequencing

We found that multilayered phosphorylation of human Tob2 modulates its PABP-binding ability to change global deadenylation and mRNA turnover, which in turn reprograms transcriptome to influence cell proliferation. SOURCE: Ann-Bin Shyu The University of Texas Health Science Center at Houston