Pluto Bioinformatics

GSE140740: Random mono-allelic expression in MECP2-mutated cells

Bulk RNA sequencing

To improve our knowledge on this largely unknown phenomenon, and to study the role of MeCP2 in RMAE, we compared RMA gene expression profiles in clonal cell cultures expressing wild-type MeCP2 versus mutant MeCP2 from a RTT patient carrying a pathogenic non-sense variant. SOURCE: Thierry Bienvenu (thierry.bienvenu@inserm.fr) - INSERM