Pluto Bioinformatics

GSE107919: Chromatin remodeler CHD8 in CNS myelination and remyelination

Bulk RNA sequencing

Mutations in CHD8, an ATP-dependent chromodomain-helicase-DNA-binding protein 8, are known to cause a set of Autism Spectrum Disorders (ASD). We found that CHD8 is highly expressed in myelinating oligodendrocytes (OL) and their progenitors in the developing central nervous system (CNS).We performed CHD8 chIP-seq analysis in cultured oligodendrocytes. SOURCE: Richard LuLu Lab,T6.525 Cincinnati Children's Hospital Medical Center