Pluto Bioinformatics

GSE57533: Altered epigenetic programming links intestinal inflammation to colon cancer (RNA-seq)

Bulk RNA sequencing

This study uses whole-transcriptome sequencing to characterize the transcriptomes of the AOM/DSS mouse model. In this model, mice are treated with dextran sodium sulfate (DSS) to induce colitis. When this treatment is preceded by injections of the weak carcinogen azoxymethane (AOM) the mice develop intestinal tumors. Our results identify sets of differentially expressed genes which are correlated with methylation changes of the corresponding genes. SOURCE: Guenter Raddatz German Center for Cancer Research