Pluto Bioinformatics

GSE98974: Adult CNS Myelin Enhances Axonal Outgrowth From Neural Stem Cells

Bulk RNA sequencing

The growth of neural stem cells is strongly enhanced on myelin in vitro and in vivo. To identify the mechanisms associated with this phenome, we compared RNA expression from mouse E12 derived spinal cord cells on stimulation substrates (laminin and myelin) to permissive substrates (PDL). We identified Negr1 as mediator of the stimulatory effects of myelin. SOURCE: Riki Kawaguchi (rkawaguchi@mednet.ucla.edu) - Giovanni Coppola, Informatics Center for Neurogenetics and Neurogenomics (ICNN). University of California Los Angeles