Pluto Bioinformatics

GSE135880: EED-mediated histone methylation is critical for CNS myelination and remyelination by inhibiting WNT, BMP and senescence pathways

Bulk RNA sequencing

PRC2 catalyzes tri-methylation of histone H3 lysine residue K27 (H3K27me3), and then H3K27me3 recruits downstream regulatory factors to create a transcriptionally repressive chromatin environment. PRC2 is involved in diverse biological processes, including cell growth, cell differentiation and the maintenance of cell identity. Here, to study the role of PRC2 on oligodendrocyte myelination and remyelination, we performed RNA-seq and ATAC-seq analysis of isolated control and Eed cKO mouse OPCs. SOURCE: Richard LuLu Lab,T6.525 Cincinnati Children's Hospital Medical Center