Pluto Bioinformatics

GSE139178: RNA-seq of prostate cancer cell lines with acquired resistance to AKT inhibitors GDC-0068 (ATP competitive) or MK206 (allosteric)

Bulk RNA sequencing

Goal: Study resistance mechanisms to ATP-competitive vs. allosteric AKT inhibitors, in prostate cancer; Methods: RNA-sequencing; Results: Resistance to the ATP-competitive inhibitor GDC-0068 was driven by compensatory activity of parallel signaling pathways SOURCE: Anneleen Daemen (anneleen.daemen@gmail.com) - GENENTECH, INC.