Pluto Bioinformatics

GSE71679: Effect of Smyd1 conditional knockout on gene expression in skeletal muscle

Bulk RNA sequencing

Transcriptome analysis by RNA-seq of tibialis anterior muscle from control and Smyd1 myocyte-specific conditional knockout mice at 6 weeks of age. Smyd1 is a methyltransferase specifically expressed in striated muscle and CD8+ T cells. Smyd1 deficiency resulted in centronuclear myopathy primarily affecting fast-twitch muscle fibers. These results provide insight into how loss of Smyd1 altered transcriptional programs resulting in centronuclear myopathy. SOURCE: M. David Stewart University of Houston