The study examined early transcriptional changes in the brain of different mouse models of spinocerebellar ataxia type 3, a dominantly-inherited neurodegenerative disease caused by a CAG repeat expansion in the ATXN3 gene. The goal was to identify early transcriptional signatures that are strongly associated with the accumulation and aggregation of the disease protein, ataxin-3, in the brain. The study also investigated the extent to which the observed transcriptional changes might be contributors to disease pathogenesis. SOURCE: Yao Xiao (yxiaoy@umich.edu) -  UNIVERSITY OF MICHIGAN

Pluto Bioinformatics

GSE117605: Transcriptional changes in mouse models in SCA3