Pluto Bioinformatics

GSE81555: Determination of Lsd1 function in brown adipose tissue by global transcriptome analysis [RNA-seq]

Bulk RNA sequencing

To investigate the role of Lsd1 in BAT, we crossed mice harboring conditional Lsd1 alleles (Zhu et al., 2014) with the Ucp1-Cre deleter strain (Turpin et al., 2014), which results in Cre-mediated loss of Lsd1 selectively in brown adipocytes. Transciptome analysis of BAT obtained from control and knock-out mice revealed 3322 genes differentially expressed between Lsd1 knock-out and control mice at 10 weeks of age (p-value<10-2). SOURCE: Dominica Willmann (dominica.willmann@uniklinik-freiburg.de) - Uniklinik-Freiburg