Pluto Bioinformatics

GSE81492: APOL1 variant expression in mouse podocytes cause kidney disease

Bulk RNA sequencing

Next-generation sequencing (NGS) has become an important tool in molecular charactarization of animal models. APOL1 variants are associated with end stage renal disease in African Americans. We developed a mouse model with podocyte specific over expression of APOL1. Differential molecular signatures were identified between the groups by RNA-Sequencing on kidney. SOURCE: Chengxiang Qiu (chengxq@mail.med.upenn.edu) - University of Pennsylvania