Pluto Bioinformatics

GSE78845: Single cell transcriptome analysis of mouse thoracic sympathetic ganglia

Bulk RNA sequencing

We explore the heterogeneity of mouse thoracic ganglia demonstrating the presence of an unexpected variety of cell-types and identify specialized populations of nipple- and pilo-erector muscle neurons. These neurons extend axonal projections and are born amongst other neurons during embryogenesis, but remain unspecialized until target organogenesis occurs postnatally. Target innervation and cell-type specification is coordinated by an intricate acquisition of unique combinations of growth factor receptors and the initiation of expression of concomitant ligands by the nascent erector muscles. SOURCE: Sten LinnarssonMolecular Neurobiology Karolinska Institutet