Interferons and its downstream pathway play pleiotropic roles in antitumor reaction. However, targeting IFN pathway is unsatisfied due to unpredictable effects. Exploiting players other than known proteins involved in IFN pathway is pivotal for targeting this pathway. In our study, we comprehensively analyzed IFN-regulated lncRNAs and identified the top-ranking candidate IRF1-AS which functions as a positive regulator of IFN response and a tumor suppressor in ESCC. We also identified a positive feedback loop between IRF1-AS and IRF1, which was supposed to maintain the positive feedback loop between IFN signaling and IRF1-AS. SOURCE: Jianbing Huang (huangjb105419@qq.com) -  Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences

Pluto Bioinformatics

GSE124514: Interferon-regulated lncRNA analysis identifies IRF1-AS as a tumor suppressor in esophageal squamous cell carcinoma (ESCC)