Pluto Bioinformatics

GSE52870: Pax5 restoration in a mouse model of B progenitor acute lymphoblastic leukemia

Bulk RNA sequencing

Hypomorphic mutations of PAX5 occur in one third of B-progenitor acute lymphoblastic leukemias (B-ALLs), however their functional consequences remain undefined. Here we employ advanced transgenic RNAi in mice to suppress endogenous Pax5 expression in the hematopoietic compartment in vivo, which co-operates with activated STAT5 to induce B-ALL. In this model, restoring endogenous Pax5 expression in established B-ALL induces transcriptional and immunophenotypic changes reminiscent of normal B cell differentiation, disabling leukemia-initiating capacity and ultimately causing leukemia clearance. SOURCE: Gordon,K,Smyth (smyth@wehi.edu.au) - Smyth Walter and Eliza Hall Institute of Medical Research