Pluto Bioinformatics

GSE90715: Hijacking of stress response machinery by oncogenes in acute leukaemia [RNA-seq]

Bulk RNA sequencing

Our data demonstrate binding of NOTCH1 on the promoters of HSF1 and HSF1 targets. We performed RNA-seq upon control conditions, inhibition of the NOTCH1 pathway by gSI, HSF1 knockdown and combination of HSF1 knockdown and gSI treatment. Our results show that NOTCH1 regulates the expression of heat shock response genes. Moreover, combination of HSF1 downregulation and gSI treatment further decreased the expression of heat shock response genes compared to single treatments. SOURCE: Nikos Kourtis (nkourtis@gmail.com) - NYU School of Medicine