Pluto Bioinformatics

GSE99888: Singlecell transcriptomic analysis of mouse CA1 inhibitory neurons

Bulk RNA sequencing

We studied the transcriptomes of mouse CA1 inhibitory cells. Novel clustering methods identified all 23 previously described CA1 inhibitory types, while also suggesting 6 new inhibitory classes. Latentfactor analysis revealed a common continuum of expression of many genes within and between classes, which we hypothesized correlates with a continuum from fasterspiking cells that proximally target pyramidal cells, to slower active cells targeting pyramidal distal dendrites or interneurons. SOURCE: Sten LinnarssonMolecular Neurobiology Karolinska Institutet