Pluto Bioinformatics

GSE71595: RNA-sequencing of cells derived from the site of inflammation of Juvenile Idiopathic Arthritis patients

Bulk RNA sequencing

Through RNA sequencing of CD4+ Tmemory/effector cells derived from the synovium of JIA patients and healthy controls, we analyzed the JIA gene expression signature. Treatment of autoinflammatory site-derived patient T cells with the BET-inhibitor JQ1 inhibited immune-related super-enhancers and preferentially reduced disease-associated gene expression, including cytokine-related processes. SOURCE: Janneke Peeters (j.g.c.peeters-7@umcutrecht.nl) - UMC Utrecht