RNA sequencing confirmed that both E and CLA increased the expression of genes involved in proliferation and cell cycle progression. The transcriptome of the mammary glands from E-treated mice was characterized by canonical E-induced genes including Pgr and Areg, whereas CLA differentially regulated the expression of genes implicated in inflammation  a finding in-line with perturbation of the mammary stroma stimulated by CLA. SOURCE: Grace,E,Berryhill (geberryhill@ucdavis.edu) - Russell C Hovey Laboratory University of California, Davis

Pluto Bioinformatics

GSE94121: The transcriptome of estrogen-independent mammary growth induced by dietary conjugated linoleic acid