Many studies have reported that human embryonic stem (hES) cells have an exceptional ability to repair damaged DNA. Moreover, unlike differentiated cells, hES cells have features and mechanisms such as apoptosis prone mitochondria, which prevent any changes in genetic information caused by DNA damage to be transmitted to their descendants. Type-A (dark) spermatogonia and cancer stem cells are thought to be dormant. However, hES cells, the so-called stem cells used in regenerative medicine, generally have a high proliferative capacity. This suggests that in these cells, oxidative DNA damage associated with vigorous proliferation and DNA scission associated with replication occur frequently. We performed RNA sequencing to analyze the expression of DNA repair-related genes in hES cells. SOURCE: Daisuke Okuzaki (dokuzaki@biken.osaka-u.ac.jp) -  Research institute for microbial diseases, Osaka university

Pluto Bioinformatics

GSE138093: High level DNA repair gene expression in human ES cells