Purpose: RNA-Seq analysis can help identify large set of differentially expressed genes at a time. We performed RNA-Seq analysis to identify differentially expressed genes in the PBMCs of war veterans suffering from PTSD.;	Methods: Total RNA from PBMCs from PTSD +ve and -ve individuals were used for RNA-Seq analysis.;	Results: We obtained, on average, ~60 millions reads per sample. More than 70% of the reads were mapped to human genome. Functional analysis of the differentially expressed genes (362) revealed dysregulation in immune system network.;	Conclusions: Our present study provides further proof that immune system related genes and pathways are dysregulated in PTSD PBMCs. SOURCE: Mitzi Nagarkatti (mnagark@uscmed.sc.edu) - Nagarkatti lab University of South Carolina School of Medicine

Pluto Bioinformatics

GSE83601: Dysregulated immune system networks in war veterans with PTSD