Pluto Bioinformatics

GSE115550: Spatially Constrained Tandem Bromodomain Inhibition Bolsters Sustained Repression of BRD4 Transcriptional Activity for TNBC Cell Growth

Bulk RNA sequencing

We performed RNA-seq of MDA-MB-231 cells that were treated with MS645 or JQ1 at 50 nM and 500 nM in an effort to understand how MS645 exerts such a profound cell growth inhibition on cancer cells. SOURCE: MING-MING ZHOU (ming-ming.zhou@mssm.edu) - Icahn School of Medicine at Mount Sinai