Pluto Bioinformatics

GSE145053: Cortical kidney bulk RNA Sequencing in the reversible unilateral ureter obstruction model.

Bulk RNA sequencing

The kidney has limited capacity to regenerate following injury and preferentially repairs chronic injury with secreted extracellular matrix proteins. This can be a progressive process with functioning kidney tissue being replaced detrimentally with fibrotic scar tissue, ultimately leading to kidney failure. Using the reversible unilateral ureteric obstruction model, a model of reversable injury, we describe the transcriptomic changes that occur during obstructive renal injury and subsequent repair. SOURCE: Laura Denby (laura.denby@ed.ac.uk) - University of Edinburgh