Pluto Bioinformatics

GSE122840: Gene expression analysis of mouse BNST and blood cells after chronic social defeat stress (CSDS)

Bulk RNA sequencing

Chronic psychosocial stress is a risk factor for psychiatric disorders, and genetic factors interact in conferring susceptibility. The chronic social defeat stress (CSDS) mouse model allows identifying factors underlying resilience and susceptibility to chronic psychosocial stress. Following 10 days of CSDS, we collected the brain and blood tissues. We performed (1) AGO2 RNA immunoprecipitation-sequencing (AGO2 RIP-seq) of active miRNAs and their mRNA targets in the BNST. Additionally, we carried out RNA-seq and miRNA-seq from blood cells. SOURCE: Iiris Hovatta (iiris.hovatta@helsinki.fi) - Neurogenomics University of Helsinki