The aim of this study is to investigate a role of glycolysis in transcriptional programing of Th17 cells during differentiation.  Nave CD4 T cells were differentiated towards Th17 cells with or without a mild inhibition of glycolysis, and transcriptome signature was analyzed.  We found about 200 transcripts were differentially regulated.  Further pathway analysis suggested that glycolysis controls genes associated with IL-2/STAT5 signaling during Th17 differentiation.  Inhibition of glycolysis resulted in enrichment of genes associated with translational processes and Th17 signature genes. SOURCE: Laurie,E,Harrington (boyoung@uab.edu) -  University of Alabama at Birmingham

Pluto Bioinformatics

GSE115339: Transcriptional profile of Th17 cells: The role of glycolysis