Pluto Bioinformatics

GSE119118: Gene expression profile in mouse back skin after cyclophosphamide treatment

Bulk RNA sequencing

Chemotherapy-induced hair loss (alopecia; CIA) is a highly distressing adverse effect that many cancer patients endure. Yet the molecular pathobiology of CIA remains largely unknown. We analysis the changes of mRNA profiles at different time points after cyclophosphamide treatment using Next-generation Sequencing in a mouse model of CIA. Our result revealed that Shh signaling is an evolutionarily conserved key target in CIA pathobiology. SOURCE: Qingxiang Gao (fzgqx@sina.com) - Fuzhou university