Pluto Bioinformatics

GSE108392: The influence of PPFIA1 silencing to gene expression in breast carcinoma cell line and head and neck squamous cell carcinoma cell lines by RNA-sequencing in three dimensional collagen I

Bulk RNA sequencing

PPFIA1 (encodes for liprin-1) locates at the commonly amplified 11q13 region in cancer, but the precise mechanism of liprin-1 function has remained unclear. In this study we show how genes are differentially expressed after liprin-1 knockdown in different cell lines, grown in three dimensional matrix. The overall goal was to gain insight into the mechanism by which liprin-1 has an effect on the progression of head and neck carcinomas and breast carcinomas in three dimensional environment. SOURCE: Outi Monni (outi.monni@helsinki.fi) - University of Helsinki