Pluto Bioinformatics

GSE115121: TAF1 is critical for AE driven leukemogenesis [RNA-seq]

Bulk RNA sequencing

TAF1 is essential for AE driven leukemogenesis. Depletion of TAF1 impairs the recruitment of AE to its target genes, interfering with its control of gene expression. The bromodomains of TAF1 associate with K43 acetylated AE and this association plays a role in the proliferation of AE expressing AML cells. SOURCE: Stephen Nimer University of Miami