Treatment of severely refractory Crohns disease (CD) patients remains a clinical challenge. Recent studies show the efficacy of autologous hematopoietic stem cell transplant (HSCT) in these severely compromised patients. HSCT is thought to eliminate auto-reactive cells; however, no specific studies of immune reconstitution in CD patients are available. We studied a group of CD patients receiving autologous HSCT, with 50% of them achieving endoscopic drug-free remission. To elucidate the mechanism driving efficacy, we studied changes in the immune cell composition in tissue induced by HSCT. SOURCE: Azucena Salas (asalas1@clinic.ub.es) -  IDIBAPS

Pluto Bioinformatics

GSE115390: Differences in tissue immune cell populations following hematopoietic stem cell transplantation in Crohns disease patients