Pluto Bioinformatics

GSE100261: Transcriptional impact of MTHFD2 in Human Aortic Endothelial Cells

Bulk RNA sequencing

We performed transcriptome analysis of Human Aortic Endothelial Cells after siRNA mediated knockdown of MTHFD2. We identified MTHFD2 as a key driver for a gene cluster which integrates mitochondrial one-carbon metabolism, serine synthesizing enzymes as well as common amino acid and ER stress response genes. SOURCE: Jun Zhu (jun.zhu@mssm.edu) - Icahn school of medicine at mount sinai