Pluto Bioinformatics

GSE108438: The chromatin remodeler Bptf activates a stemness gene-expression program essential for the maintenance of adult hematopoietic stem cells [RNA-Seq]

Bulk RNA sequencing

Bptf, a component of NURF chromatin-remodeling complex, is essential for maintaining the pool size and function of hematopoietic stem cells (HSCs). Genome-wide transcriptome profiling revealed that Bptf loss caused down-regulation of HSC-specific gene-expression programs, which included master transcription factors (such as Meis1, Pbx1, and Lmo2) known to be required for HSC maintenance and self-renewal. Bptf directly bound to the promoter of stemness TF genes, potentiating their transcription and DNA accessibility. SOURCE: Greg Wang (greg_wang@med.unc.edu) - UNC-Chapel Hill School of Medicine