Pluto Bioinformatics

GSE115059: Transcriptomic analysis of the role of the integrin a6b4 in detached cells

Bulk RNA sequencing

Analysis of gene expression profiles of matrix-detached cells with and without expression of ITGB4, in clustering and non-clustering conditions. The experiment tested the hypothesis that the integrin beta 4 (ITGB4) mediates a significant amount of pro-survival signaling in matrix-detached conditions. Expression of ITGB4 in cancer is correlated with poor patient survival and is impliated in increased metastatic spread. Survival in matrix-deprived conditions is essential to metastasis and targeting signaling downstream of the integrin beta 4 may help curtail metasasis. SOURCE: Jennifer Benanti (Jennifer.Benanti@umassmed.edu) - UMass Medical School