Pluto Bioinformatics

GSE108362: Spontaneous DIPG Modeling Reveals Novel H3.3 K27M-Mediated Oncogenic Mechanisms Acting Through Epigenetic Effects [RNA-seq]

Bulk RNA sequencing

A mouse knock-in model engineered for Cre recombinase-activated expression of the endogenous mouse H3f3a allele generating an epitope-tagged H3.3 equipped with or without a K27M mutation to investigate H3.3 K27M effects on brain cell and tumor growth, gene expression and epigenetics. SOURCE: Suzanne,J,Baker (Suzanne.Baker@STJUDE.ORG) - St Jude Children's Research Hospital