Pluto Bioinformatics

GSE110564: Mycobacterium tuberculosis cording in lymphatic endothelial cells (hLEC)

Bulk RNA sequencing

Mycobacterium tuberculosis (Mtb) displayed cording phenotypes during intracellular infection. RNA-Seq was used to identify transcriptional programmes expressed by hLEC that actviates pathways relating to cellular pro-survival and cyosolic surveillance of intracellular Mtb. Mtb cording was found to be a mechanism to evade xenophagy in the cytosol of endothelial cells. SOURCE: Rachel Lai (rachel.lai@crick.ac.uk, rachel.lai@imperial.ac.uk) - Tuberculsosis Laboratory The Francis Crick Institute