Pluto Bioinformatics

GSE119049: Toxicity of LCDD monoclonal Ig free light chains on renal glomeruli

Bulk RNA sequencing

We analyzed the transcriptome (RNA-seq) of glomeruli in a mouse model of light chain deposition disease (LCDD) as compared to control mice (WT and DH-LMP2A, the latter producing no complete immunoglobulins, only free Ig light chains).; Kidney lesions in LCDD are due to the deposition of an abnormal monoclonal free Ig light chain and comprise progressive thickening of basement membranes (tubular and glomerular) and nodular glomerulosclerosis resembling the lesions observed in diabetic nephropathy.; The aim of the present study is to analyse the transcriptomic changes at early steps of glomerulosclerosis. SOURCE: Kevin LebrigandFunctional Genomics Platform of Nice-Sophia-Antipolis, France. IPMC/CNRS