Pluto Bioinformatics

GSE108278: Transcriptional profiling of growing and senescent WT and IL-1R-depleted IMR90 cells

Bulk RNA sequencing

Senescent cells no longer divide, but remain metabolically active and secrete an array of cytokines, growth factors, and proteases termed the senescence-associated secretory phenotype (SASP). Previous studies have indicated that the SASP factor IL-1 may be an upstream regular of the SASP. We show here that knockdown of the IL-1 receptor IL-1R results in a sizable reduction of SASP expression late in senescence induction. Our results suggest that targeting the IL-1 signaling pathway is a reliable method to dissociate the SASP from cell-cycle exit. SOURCE: Lena Lau (lena.lau@nyumc.org) - NYU School of Medicine