Pluto Bioinformatics

GSE119048: Intrinsic toxicity of LCDD monoclonal Ig free light chain on plasma cells (PC)

Bulk RNA sequencing

We analyzed the transcriptome (RNA-seq) of mouse plasma cells (PC) expressing a human Ig light chain from a patient suffering light chain deposition disease (LCDD) as compared to control plasma cells (WT and DH-LMP2A, the latter producing no complete immunoglobulins, only free Ig light chains).; Ig light chains causing LCDD present structural peculiarities leading to their aggregation and deposition into tissues and organs, mainly the kidney. We sought to determine if plasma cells producing these abnormal Ig could present specific phenotypes.; The aim of the present study is to analyse the transcriptomic signature of plasma cells producing abnormal Ig free light chains. SOURCE: Kevin LebrigandFunctional Genomics Platform of Nice-Sophia-Antipolis, France. IPMC/CNRS