Pluto Bioinformatics

GSE108315: De novo formation of a functional biliary system by TGF-mediated hepatocyte transdifferentiation

Bulk RNA sequencing

We observed de novo formation of peripheral bile ducts by transdifferentiation of hepatocytes in mice born without peripheral bile ducts. To assess the authenticity and maturity of the hepatocyte-derived peripheral cholangiocytes forming the new bile ducts, we compared their global gene expression profile to that of peripheral cholangiocytes isolated from normal mice. We also included hepatocytes isolated from mice born without peripheral bile ducts as a control. SOURCE: Rebekah Karns (Rebekah.Karns@cchmc.org) - Cincinnati Children's Hospital Medical Center