Pluto Bioinformatics

GSE109908: RNA seq from liver samples of C57BL/6 mice to study the gene expression synchrony of Plasmodium stages with host circadian cycle.

Bulk RNA sequencing

The Plasmodium life cycle parasites differentiate and proliferate synchronously, paralleling the vertebrate host's circadian rhythm. Here we report that expression of carbohydrate metabolism and inflammatory genes in IFN-primed leukocytes and liver cells from infected mice are boosted in P. chabaudi-infected mice. In addition, a rhythmic gene expression of PPARG and TNF, which are key regulators of glucose metabolism, parallel blood glucose levels across the circadian cycle in infected mice. SOURCE: Ricardo,Tostes,Gazzinelli (ricardo.gazzinelli@umassmed.edu) - Infectious Diseases and Immunology University of Massachusetts Medical School