Pluto Bioinformatics

GSE93935: Studying iPSCs from a hibernating mammal reveals molecular mechanisms of cold resistance in neural tissues

Bulk RNA sequencing

To explore the cold resistant feature of ground squirrel neuron cells, we compared transcriptomes of human and ground squirrel iPSC derived neurons in the response to cold treatment. We identified several key pathways that are critical for the maintenance of neuronal microtubule cytoskeleton integrity at low temperature. SOURCE: Yizhao Luan ( - Sun Yat-sen university

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