miRNA-1343 is an uncharacterized miRNA predicted to target a number of genes involved in epithelial cell function including TGF-beta signaling, cell adhesion, and cell proliferation. We transiently overexpressed miRNA-1343 or a non-targeting control miRNA in A549 and 16HBE14o- human airway cell lines. As predicted, RNA-seq following miRNA-1343 overexpression showed significant downregulation of genes involved in these pathways. Furthermore, genes involved in cholesterol and lipid biosynthesis were found to be significantly upregulated by miRNA-1343 overexpression. SOURCE: Ann Harris (ann-harris@northwestern.edu) - Ann Harris Lab Northwestern University

Pluto Bioinformatics

GSE75591: miRNA-1343 attenuates pathways of fibrosis by targeting the TGF-beta receptors [RNA-seq]