Pluto Bioinformatics

GSE148263: The ubiquitin ligase TRIM37 controls cancer-specific vulnerability to PLK4 inhibition

Bulk RNA sequencing

We show synthetic lethality between PLK4 inhibition-mediated centrosome loss and the overexpression of the ubiquitin ligase TRIM37 in cancer cells with amplification of Chr17q SOURCE: Karen Oegema (koegema@health.ucsd.edu) - UCSD