Pluto Bioinformatics

GSE134555: Endothelial TGFb signaling drives vascular inflammation and atherosclerosis [bulk RNA-Seq]

Bulk RNA sequencing

Endothelial TGF signaling is one of the primary drivers of atherosclerosis-associated vascular inflammation. Inhibition of endothelial TGF signaling in hyperlipidemic mice reduces vessel wall inflammation and vascular permeability and leads to arrest of disease progression and regression of established lesions. We performed scRNAseq method to examine endothelial cell gene expression profile using Apoe and EC specific TGFbR1/2 KO in Apoe background mice. SOURCE: Michael Simons (michael.simons@yale.edu) - Yale Cardiovascular Research Center Yale University