Pluto Bioinformatics

GSE135330: Microglial microRNAs mediate sex-specific responses to tau pathology

Bulk RNA sequencing

Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by miRNAs, but it is unknown whether microglial miRNAs have sex-specific influences on disease. We show that microglial miRNA expression differs in males and females, and loss of miRNAs leads to sex-specific changes in the microglial transcriptome and to tau pathology. These findings suggest microglial miRNAs influence tau pathogenesis in a sex-specific manner. SOURCE: Lay Kodama (lay.kodama@gladstone.ucsf.edu) - University of California San Francisco