We aimed at characterizing the response to reduced cPLA2 activity in metastatic versus non-metastatic cells.;	We employed an isogenic murine cell line pair displaying metastatic (4T1) and non-metastatic (67NR) phenotype to investigate the role of cPLA2 on migration. Further, we elucidate the effect of reduced cPLA2 activity on global gene expression in the metastatic cell line;	We found that cPLA2 inhibition may inhibit metastasis through an anti-migratory effect, possibly involving Toll-like receptor signaling and type I interferons SOURCE: Hanna Maja TunsetMR Cancer NTNU

Pluto Bioinformatics

GSE138026: Cytosolic phospholipase A2 alpha regulates TLR signaling and migration in metastatic 4T1 cells