Pluto Bioinformatics

GSE149356: Single cell RNA-seq reveals high heterogeneity among human T cells.

Bulk RNA sequencing

Human T cells take a small but important part in the immune system. Human T cells are usually categorized by the V gene of their T cell receptor (TCR) chain; most of which are V1+ or V2+. Naive T cells are often found from neonates and cytotoxic T cells (CTLs) are frequent in adults. However, phenotypes and the developmental programs of human T cells are not fully clear. Here, by single-cell RNA sequencing (sc-RNAseq) of transcriptome and T cell receptor (sc-TCRseq) on T cells from neonates and adults, we revealed human T cells can be divided as nave T cells, CTLs, and NKT cells which are featured by pro-V1, V1, and V2 TCR repertoire, respectively. NKT cells can be further described as NKT-1, NKT-2, and NKT-17 cells. SOURCE: Immo Prinz (prinz.immo@mh-hannover.de) - Hannover Medical School