Pluto Bioinformatics

GSE35126: Effects of Cardiac Glycosides on RNA Expression in Prostate Cancer LNCaP-abl Cells

Bulk RNA sequencing

Prostate cancer is the most common cancer in men and cardiac glycosides inhibit prostate cancer cell proliferation. In order to investigate the mechanism by which cardiac glycosides inhibit prostate cancer cells, we observed genome-wide RNA expression in prostate cancer LNCaP-abl cells, hormone resistant cells, after the cardiac glycoside treatment using RNA-Seq. In addition, we profiled LNCaP-abl cells after androgen receptor (AR) knockdown to observe whether cardiac glycoside effect on RNA expression is similar to that of AR knockdown. SOURCE: Hai-Ri Li (hairili@ucsd.edu) - Dr. Xiang-Dong Fu University of California, San Diego